Combating Drug Resistant Gram-negative Infections: Giving Conventional Antibodies New Capabilities
Credits: 1.0 AMA PRA Category 1 Credit™, 1.0 nursing contact hours, 1.0 ACPE Credits
Gram-negative (GN) bacterial infections present a daunting challenge for clinicians, as they can be especially hard to treat and are associated with high morbidity and mortality, particularly when dealing with carbapenem-resistant Enterobacteriaceae (CRE) and other antibiotic-resistant pathogens. While the development of novel antibiotic classes to overcome resistance has been lacking, recent advances in the development of next-generation agents as of well-established classes has the potential to help address the critical need for effective therapies for serious, drug-resistant GN infections. As such, it is crucial for members of the infectious disease clinical team who treat these patients to understand how these emerging therapies differ from their more conventional predecessors, how they may effectively fit into current treatment paradigms, and how to effectively approach dosing and therapeutic drug management in order to optimize health outcomes for these difficult-to-treat patients.